The song plays during the opening scene montage. Meredith and Christina dance, Alex and are kissing when she asks him if he's okay, Christina tells Lexie she was brave for doing what she did that day, Callie sits in a room with Sloan while he contemplates his case, George lays in bed looking at Izzie over her shoulder while she is thoughtful, and Meredith tells Derek she doesn't want him dating other people.

The song plays as Meredith relays Ray's message to Stan's wife and they talk about her losing her husband and going on, even if it's the most painful thing she's ever had to do. Bailey operates on the man with the swastika tattoo on his belly. The chief fights to save Ray's life in the operating room as Meredith watches and Izzie assists. Erica works on Jacob and tells him over and over that he will not die. Derek works on Mary. Mark works on Nick as Lexie begs him to please live.